Giacomo Gianniotti (Dr. Andrew DeLuca)
Giacomo Gianniotti’s Dr. Andrew DeLuca was killed off in the season 17 midseason premiere following a heroic battle to stop a sex trafficker that capped the actor’s seven-season run on the Shondaland drama. DeLuca, who was stabbed and ultimately died in surgery, became only the fifth series regular in Grey’s Anatomy history to have their storyline end in a fatality and the first since Patrick Dempsey’s shocking exit nearly six years ago.