The biggest change for gameplay is the switch to a first-person perspective, which places you on stage looking out at the crowd who'll react in real time to how well you play. Alongside this, the new GHTV mutliplayer mode enables you to challenge friends or random players.
For more on what to expect from Guitar Hero, as well as how all the changes come together to make the experience feel, check out our in-depth impressions. Luke Karmali is IGN's UK News Editor. You too can revel in mediocrity by following him on Twitter.