Window seat or aisle?
Window, if you know what's good for you.
You get a nice view and you have less chance of being exposed to germs and landing with a holiday-ruining bug.
Researchers from the University of Arizona collected swabs from the 20 most frequently touched parts of an aircraft - on more than 20 different flights.
People are often concerned about the recirculation of air in the cabin - but that should be the least of their worries.
Dishing out advice how to best avoid bugs and germs while you're locked in a metal tube with a few hundred other germ carriers, Dr Charles Gerba dispelled some popular myths.
"Usually the air is not much of a problem because it goes around and is filtered," he said.
"So when we’ve seen cases of influenza on aircraft, it’s usually only the person right next to them that has to worry."
Monitoring arm-rests, taps, sinks, trays, seat pockets, overhead lockers and toilet handles, Gerba found aisle seats collected more germs than those in the middle or by the window.
He believes this is because they are touched by so many people as they make their way through the aircraft.
He also advised against stilling in the aisle seat for this reason.
Dr Gerba also advised passengers not to use the plane's toilets - which may be tricky on a long haul flight.
The microbiologist described the loos and the "germiest" you're going to come across - as they are used by around 75 people and aren't cleaned during the flight.
"If you can hold it, hold it," he said in an interview for American TV.
"You’re more likely to pick up something from going to the bathroom than just sitting in your seat."
He added that passengers should be wary of the drop down table: "[They] often have large numbers of bacteria because they’re not commonly disinfected and cleaned between every flight."
And, whatever you do, don't go rummaging through the pocket in front of you. The in-flight magazines can share that space with discarded tissues, rubbish and bits of discarded food.
It might easiest cancelling the holiday and staying at home. In an inflatable plastic bubble.
If you can't avoid it and definitely have to get on a plane, Dr Gerba advises regularly rubbing your hands with sanitising gel.
Before you take off, give everything around you a thorough clean with disinfectant wipes.