My Bibliography

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Chen M, Fang Y, Ge Y, Qiu S, Dworkin L, Gong R. The redox-sensitive GSK3β is a key regulator of glomerular podocyte injury in type 2 diabetic kidney disease. Redox Biol. 2024 Mar 16;72:103127. doi: 10.1016/j.redox.2024.103127. [Epub ahead of print] PubMed PMID: 38527400; PubMed Central PMCID: PMC10979123.

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Chen B, Guan X, Gunning WT, Ge Y, Gohara AF, Dworkin LD, Gong R. Negative Modulation of B Cell Activation by Melanocortin 1 Receptor Signaling Protects against Membranous Nephropathy. J Am Soc Nephrol. 2023 Mar 1;34(3):467-481. doi: 10.1681/ASN.2022050605. Epub 2022 Nov 29. PubMed PMID: 36446431; PubMed Central PMCID: PMC10103281.

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Guan X, Chen B, Malhotra DK, Gohara AF, Dworkin LD, Gong R. Hematopoietic-specific melanocortin 1 receptor signaling protects against nephrotoxic serum nephritis and mediates the beneficial effect of melanocortin therapy. Kidney Int. 2023 Feb;103(2):331-342. doi: 10.1016/j.kint.2022.09.025. Epub 2022 Oct 28. PubMed PMID: 36374665; PubMed Central PMCID: PMC10431720.

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Corrigendum to Fang Y, Chen B, Gong AY, et al. "The ketone body β-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults." Kidney Int. 2021;100:1037-1053. Kidney Int. 2022 Jun;101(6):1301-1302. doi: 10.1016/j.kint.2022.04.002. PubMed PMID: 35597599; PubMed Central PMCID: PMC9387735.

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Fang Y, Chen B, Liu Z, Gong AY, Gunning WT, Ge Y, Malhotra D, Gohara AF, Dworkin LD, Gong R. Age-related GSK3β overexpression drives podocyte senescence and glomerular aging. J Clin Invest. 2022 Feb 15;132(4). doi: 10.1172/JCI141848. PubMed PMID: 35166234; PubMed Central PMCID: PMC8843754.

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Fang Y, Chen B, Gong AY, Malhotra DK, Gupta R, Dworkin LD, Gong R. The ketone body β-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults. Kidney Int. 2021 Nov;100(5):1037-1053. doi: 10.1016/j.kint.2021.06.031. Epub 2021 Jul 8. PubMed PMID: 34246657; PubMed Central PMCID: PMC8889914.

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Shaffner J, Chen B, Malhotra DK, Dworkin LD, Gong R. Therapeutic Targeting of SGLT2: A New Era in the Treatment of Diabetes and Diabetic Kidney Disease. Front Endocrinol (Lausanne). 2021;12:749010. doi: 10.3389/fendo.2021.749010. eCollection 2021. Review. PubMed PMID: 34790170; PubMed Central PMCID: PMC8591164.

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Sharif S, Chen B, Brewster P, Chen T, Dworkin L, Gong R. Rationale and Design of Assessing the Effectiveness of Short-Term Low-Dose Lithium Therapy in Averting Cardiac Surgery-Associated Acute Kidney Injury: A Randomized, Double Blinded, Placebo Controlled Pilot Trial. Front Med (Lausanne). 2021;8:639402. doi: 10.3389/fmed.2021.639402. eCollection 2021. PubMed PMID: 34195206; PubMed Central PMCID: PMC8236527.

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Chen B, Wang P, Liang X, Jiang C, Ge Y, Dworkin LD, Gong R. Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease. Cell Death Dis. 2021 Apr 30;12(5):432. doi: 10.1038/s41419-021-03709-5. PubMed PMID: 33931588; PubMed Central PMCID: PMC8087712.

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Chang M, Chen B, Shaffner J, Dworkin LD, Gong R. Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities. Front Physiol. 2021;12:651236. doi: 10.3389/fphys.2021.651236. eCollection 2021. Review. PubMed PMID: 33716796; PubMed Central PMCID: PMC7943476.

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Zhang J, Anshul F, Malhotra DK, Jaume J, Dworkin LD, Gong R. Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes. Antioxidants (Basel). 2021 Jan 19;10(1). doi: 10.3390/antiox10010138. PubMed PMID: 33478120; PubMed Central PMCID: PMC7835906.

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Fang Y, Gong AY, Haller ST, Dworkin LD, Liu Z, Gong R. The ageing kidney: Molecular mechanisms and clinical implications. Ageing Res Rev. 2020 Nov;63:101151. doi: 10.1016/j.arr.2020.101151. Epub 2020 Aug 22. Review. PubMed PMID: 32835891; PubMed Central PMCID: PMC7595250.

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Xu Y, Guan X, Zhou R, Gong R. Melanocortin 5 receptor signaling pathway in health and disease. Cell Mol Life Sci. 2020 Oct;77(19):3831-3840. doi: 10.1007/s00018-020-03511-0. Epub 2020 Apr 4. Review. PubMed PMID: 32248247; PubMed Central PMCID: PMC7511443.

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Guo J, Lei M, Cheng F, Liu Y, Zhou M, Zheng W, Zhou Y, Gong R, Liu Z. RNA-binding proteins tristetraprolin and human antigen R are novel modulators of podocyte injury in diabetic kidney disease. Cell Death Dis. 2020 Jun 2;11(6):413. doi: 10.1038/s41419-020-2630-x. PubMed PMID: 32487989; PubMed Central PMCID: PMC7265504.

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Qiao Y, Wang P, Chang M, Chen B, Ge Y, Malhotra DK, Dworkin LD, Gong R. Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling. Clin Sci (Lond). 2020 Apr 17;134(7):695-710. doi: 10.1042/CS20200016. PubMed PMID: 32167144; PubMed Central PMCID: PMC9870294.

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Shrivastava S, Chen B, Dworkin LD, Malhotra DK, Gong R. Relapse of Nephrotic Syndrome after Adrenocorticotropic Hormone-Induced Remission: Implications of Adrenocorticotropic Hormone Antibodies. Am J Nephrol. 2020;51(5):390-394. doi: 10.1159/000506854. Epub 2020 Mar 18. PubMed PMID: 32187600; PubMed Central PMCID: PMC7521046.

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Liang X, Chen B, Wang P, Ge Y, Malhotra DK, Dworkin LD, Liu Z, Gong R. Triptolide potentiates the cytoskeleton-stabilizing activity of cyclosporine A in glomerular podocytes via a GSK3β dependent mechanism. Am J Transl Res. 2020;12(3):800-812. eCollection 2020. PubMed PMID: 32269713; PubMed Central PMCID: PMC7137037.

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Liang X, Wang P, Chen B, Ge Y, Gong AY, Flickinger B, Malhotra DK, Wang LJ, Dworkin LD, Liu Z, Gong R. Glycogen synthase kinase 3β hyperactivity in urinary exfoliated cells predicts progression of diabetic kidney disease. Kidney Int. 2020 Jan;97(1):175-192. doi: 10.1016/j.kint.2019.08.036. Epub 2019 Oct 10. PubMed PMID: 31791666.

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Bao H, Zhang Q, Liu X, Song Y, Li X, Wang Z, Li C, Peng A, Gong R. Lithium targeting of AMPK protects against cisplatin-induced acute kidney injury by enhancing autophagy in renal proximal tubular epithelial cells. FASEB J. 2019 Dec;33(12):14370-14381. doi: 10.1096/fj.201901712R. Epub 2019 Oct 29. PubMed PMID: 31661633.

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Lu M, Wang P, Qiao Y, Jiang C, Ge Y, Flickinger B, Malhotra DK, Dworkin LD, Liu Z, Gong R. GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition. Redox Biol. 2019 Sep;26:101275. doi: 10.1016/j.redox.2019.101275. Epub 2019 Jul 17. PubMed PMID: 31349118; PubMed Central PMCID: PMC6669347.

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Guo J, Liu Z, Gong R. Long noncoding RNA: an emerging player in diabetes and diabetic kidney disease. Clin Sci (Lond). 2019 Jun 28;133(12):1321-1339. doi: 10.1042/CS20190372. Print 2019 Jun 28. Review. PubMed PMID: 31221822.

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Chen B, Wang P, Brem A, Dworkin L, Liu Z, Gong R. Mineralocorticoid receptor: A hidden culprit for hemodialysis vascular access dysfunction. EBioMedicine. 2019 Jan;39:621-627. doi: 10.1016/j.ebiom.2018.11.054. Epub 2018 Dec 5. Review. PubMed PMID: 30527626; PubMed Central PMCID: PMC6354623.

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Shaban E, Bayliss G, Malhotra DK, Shemin D, Wang LJ, Gohh R, Dworkin LD, Gong R. Targeting Regulatory T Cells for Transplant Tolerance: New Insights and Future Perspectives. Kidney Dis (Basel). 2018 Nov;4(4):205-213. doi: 10.1159/000490703. Epub 2018 Jul 31. Review. PubMed PMID: 30574497; PubMed Central PMCID: PMC6276757.

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Li J, Tang Y, Tang PMK, Lv J, Huang XR, Carlsson-Skwirut C, Da Costa L, Aspesi A, Fröhlich S, Szczęśniak P, Lacher P, Klug J, Meinhardt A, Fingerle-Rowson G, Gong R, Zheng Z, Xu A, Lan HY. Blocking Macrophage Migration Inhibitory Factor Protects Against Cisplatin-Induced Acute Kidney Injury in Mice. Mol Ther. 2018 Oct 3;26(10):2523-2532. doi: 10.1016/j.ymthe.2018.07.014. Epub 2018 Jul 17. PubMed PMID: 30077612; PubMed Central PMCID: PMC6171075.

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Lu M, Wang P, Zhou S, Flickinger B, Malhotra D, Ge Y, Tatar M, Dworkin L, Liu Z, Gong R. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-1645. doi: 10.1159/000493499. Epub 2018 Sep 18. PubMed PMID: 30227391; PubMed Central PMCID: PMC10317082.

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Lu M, Wang P, Ge Y, Dworkin L, Brem A, Liu Z, Gong R. Activation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3β pathway signaling. Sci Rep. 2018 Aug 15;8(1):12225. doi: 10.1038/s41598-018-29483-7. PubMed PMID: 30111886; PubMed Central PMCID: PMC6093907.

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Shao Q, Xia Y, Zhao M, Liu J, Zhang Q, Jin B, Xie J, Xu B, Gong R, Jiang C. Effectiveness and Safety of Peritoneal Dialysis Treatment in Patients with Refractory Congestive Heart Failure due to Chronic Cardiorenal Syndrome. Biomed Res Int. 2018;2018:6529283. doi: 10.1155/2018/6529283. eCollection 2018. PubMed PMID: 29888270; PubMed Central PMCID: PMC5985089.

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Wang P, Zhou S, Ge Y, Lu M, Liu Z, Gong R. Valproate hampers podocyte acquisition of immune phenotypes via intercepting the GSK3β facilitated NFkB activation. Oncotarget. 2017 Oct 24;8(51):88332-88344. doi: 10.18632/oncotarget.19917. eCollection 2017 Oct 24. PubMed PMID: 29179438; PubMed Central PMCID: PMC5687608.

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Wang P, Zhang Y, Wang Y, Brem AS, Liu Z, Gong R. Acquired Resistance to Corticotropin Therapy in Nephrotic Syndrome: Role of De Novo Neutralizing Antibody. Pediatrics. 2017 Jul;140(1). doi: 10.1542/peds.2016-2169. PubMed PMID: 28642375; PubMed Central PMCID: PMC5495526.

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Gong R, Wang P, Dworkin L. What we need to know about the effect of lithium on the kidney. Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1168-F1171. doi: 10.1152/ajprenal.00145.2016. Epub 2016 Apr 27. Review. PubMed PMID: 27122541; PubMed Central PMCID: PMC5210210.

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Jiang C, Zhu W, Yan X, Shao Q, Xu B, Zhang M, Gong R. Rescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease via targeting GSK3β. Sci Rep. 2016 Nov 18;6:36698. doi: 10.1038/srep36698. PubMed PMID: 27857162; PubMed Central PMCID: PMC5114614.

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Zhao K, He J, Zhang Y, Xu Z, Xiong H, Gong R, Li S, Chen S, He F. Activation of FXR protects against renal fibrosis via suppressing Smad3 expression. Sci Rep. 2016 Nov 17;6:37234. doi: 10.1038/srep37234. PubMed PMID: 27853248; PubMed Central PMCID: PMC5112546.

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Zhou S, Wang P, Qiao Y, Ge Y, Wang Y, Quan S, Yao R, Zhuang S, Wang LJ, Du Y, Liu Z, Gong R. Genetic and Pharmacologic Targeting of Glycogen Synthase Kinase 3β Reinforces the Nrf2 Antioxidant Defense against Podocytopathy. J Am Soc Nephrol. 2016 Aug;27(8):2289-308. doi: 10.1681/ASN.2015050565. Epub 2015 Dec 8. PubMed PMID: 26647425; PubMed Central PMCID: PMC4978041.

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Zhou X, Zang X, Ponnusamy M, Masucci MV, Tolbert E, Gong R, Zhao TC, Liu N, Bayliss G, Dworkin LD, Zhuang S. Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression. J Am Soc Nephrol. 2016 Jul;27(7):2092-108. doi: 10.1681/ASN.2015040457. Epub 2015 Dec 23. PubMed PMID: 26701983; PubMed Central PMCID: PMC4926973.

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Qiao Y, Berg AL, Wang P, Ge Y, Quan S, Zhou S, Wang H, Liu Z, Gong R. MC1R is dispensable for the proteinuria reducing and glomerular protective effect of melanocortin therapy. Sci Rep. 2016 Jun 8;6:27589. doi: 10.1038/srep27589. PubMed PMID: 27270328; PubMed Central PMCID: PMC4897792.

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Li C, Ge Y, Dworkin L, Peng A, Gong R. The β isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathy. J Pathol. 2016 May;239(1):23-35. doi: 10.1002/path.4692. Epub 2016 Mar 16. PubMed PMID: 26876299; PubMed Central PMCID: PMC4833638.

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Jiang C, Shao Q, Jin B, Gong R, Zhang M, Xu B. Tanshinone IIA Attenuates Renal Fibrosis after Acute Kidney Injury in a Mouse Model through Inhibition of Fibrocytes Recruitment. Biomed Res Int. 2015;2015:867140. doi: 10.1155/2015/867140. Epub 2015 Dec 29. PubMed PMID: 26885500; PubMed Central PMCID: PMC4739267.

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Li C, Ge Y, Peng A, Gong R. The redox sensitive glycogen synthase kinase 3β suppresses the self-protective antioxidant response in podocytes upon oxidative glomerular injury. Oncotarget. 2015 Nov 24;6(37):39493-506. doi: 10.18632/oncotarget.6303. PubMed PMID: 26567873; PubMed Central PMCID: PMC4741841.

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Liu Z, Gong R. Remote ischemic preconditioning for kidney protection: GSK3β-centric insights into the mechanism of action. Am J Kidney Dis. 2015 Nov;66(5):846-56. doi: 10.1053/j.ajkd.2015.06.026. Epub 2015 Aug 10. Review. PubMed PMID: 26271146; PubMed Central PMCID: PMC4623948.

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Bao H, Ge Y, Peng A, Gong R. Fine-tuning of NFκB by glycogen synthase kinase 3β directs the fate of glomerular podocytes upon injury. Kidney Int. 2015 Jun;87(6):1176-90. doi: 10.1038/ki.2014.428. Epub 2015 Jan 28. PubMed PMID: 25629551; PubMed Central PMCID: PMC4449834.

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Brem AS, Gong R. Therapeutic targeting of aldosterone: a novel approach to the treatment of glomerular disease. Clin Sci (Lond). 2015 May;128(9):527-35. doi: 10.1042/CS20140432. Review. PubMed PMID: 25671776; PubMed Central PMCID: PMC4356246.

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Yan Y, Bai J, Zhou X, Tang J, Jiang C, Tolbert E, Bayliss G, Gong R, Zhao TC, Zhuang S. P2X7 receptor inhibition protects against ischemic acute kidney injury in mice. Am J Physiol Cell Physiol. 2015 Mar 15;308(6):C463-72. doi: 10.1152/ajpcell.00245.2014. Epub 2015 Jan 14. PubMed PMID: 25588875; PubMed Central PMCID: PMC4360025.

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Wang Z, Bao H, Ge Y, Zhuang S, Peng A, Gong R. Pharmacological targeting of GSK3β confers protection against podocytopathy and proteinuria by desensitizing mitochondrial permeability transition. Br J Pharmacol. 2015 Feb;172(3):895-909. doi: 10.1111/bph.12952. Epub 2014 Dec 15. PubMed PMID: 25262943; PubMed Central PMCID: PMC4301697.

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Xu W, Ge Y, Liu Z, Gong R. Glycogen synthase kinase 3β orchestrates microtubule remodeling in compensatory glomerular adaptation to podocyte depletion. J Biol Chem. 2015 Jan 16;290(3):1348-63. doi: 10.1074/jbc.M114.593830. Epub 2014 Dec 2. PubMed PMID: 25468908; PubMed Central PMCID: PMC4340382.

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Jiang Y, Bao H, Ge Y, Tang W, Cheng D, Luo K, Gong G, Gong R. Therapeutic targeting of GSK3β enhances the Nrf2 antioxidant response and confers hepatic cytoprotection in hepatitis C. Gut. 2015 Jan;64(1):168-79. doi: 10.1136/gutjnl-2013-306043. Epub 2014 May 8. PubMed PMID: 24811996; PubMed Central PMCID: PMC4263291.

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Xu W, Ge Y, Liu Z, Gong R. Glycogen synthase kinase 3β dictates podocyte motility and focal adhesion turnover by modulating paxillin activity: implications for the protective effect of low-dose lithium in podocytopathy. Am J Pathol. 2014 Oct;184(10):2742-56. doi: 10.1016/j.ajpath.2014.06.027. PubMed PMID: 25239564; PubMed Central PMCID: PMC4188873.

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Tang J, Yan Y, Zhao TC, Gong R, Bayliss G, Yan H, Zhuang S. Class I HDAC activity is required for renal protection and regeneration after acute kidney injury. Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F303-16. doi: 10.1152/ajprenal.00102.2014. Epub 2014 May 7. PubMed PMID: 24808536; PubMed Central PMCID: PMC4121572.

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Ponnusamy M, Zhou X, Yan Y, Tang J, Tolbert E, Zhao TC, Gong R, Zhuang S. Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy. J Pharmacol Exp Ther. 2014 Aug;350(2):243-56. doi: 10.1124/jpet.113.212076. Epub 2014 May 15. PubMed PMID: 24833701; PubMed Central PMCID: PMC4109489.

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Gong L, Qu L, Li Z, Li Q, Xu H, Shen P, Pang L, Gong R, Ji G, Si J. Gene therapy with biosynthetic nanoscale peptide Cecropin A driven by the survivin promoter for hepatocarcinoma cells. J Biomed Nanotechnol. 2014 Jul;10(7):1391-9. doi: 10.1166/jbn.2014.1891. PubMed PMID: 24804559.

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Qu L, Jiang M, Li Z, Pu F, Gong L, Sun L, Gong R, Ji G, Si J. Inhibitory effect of biosynthetic nanoscale peptide Melittin on hepatocellular carcinoma, driven by survivin promoter. J Biomed Nanotechnol. 2014 Apr;10(4):695-706. doi: 10.1166/jbn.2014.1830. PubMed PMID: 24734522.