User:SveFinBioInf/ptaRNA1

Homologs of the "plasmid transferred anti-sense RNA" (ptaRNA1) were found in both Beta- and Gamma-proteobacteria. In all cases the ptaRNA1 is located anti-msense to a short protein coding gene, in Xanthomonas campestris pv. vesicatoria annotated as XCV2162. Both molecules show a very erratic phylogenetic distribution and appear only in combination. These observations are in accordance with the described Type 1 Toxin-Antitoxin systems. In these two molecule systems -- the expression of a toxic protein is regulated by a small non-coding RNA. Type 1 Toxin-Antitoxin loci are frequently found in both prokaryotic chromosomes and plasmids, and are reviewed in more detail. Template:Cite pmid Template:Cite pmid Template:Cite pmid ptaRNA1 exhibits a conserved secondary structure which is very similar to that of the FinP anti-sense RNA. Template:Cite pmid