Action research is the small intervention conducted by any practitioner. So each & every person must know the way of conducting action research. How to conduct action research that is described in this presentation.
The document contains abstracts from 4 different research studies on reading fluency interventions for students with learning disabilities or reading difficulties.
The first study found that effective interventions for building fluency include an explicit model of fluent reading, multiple opportunities for repeated reading of familiar text with feedback, and establishing performance criteria for increasing text difficulty.
The second study examined the impact of partner reading interactions on task behavior. It found that student-chosen partners led to better social cooperation, and teachers should provide scripted instructions, allow student partner choices, and avoid pairing low-ability students only with each other.
The third study was a meta-analysis that found repeated reading interventions had positive effects on reading fluency gains for students with
Action research involves applying scientific methods to solve practical problems in educational settings. It typically involves teachers or administrators studying problems within their classrooms or schools to evaluate and improve practices. Action research aims to guide educational decisions and actions through a process of studying problems scientifically. It focuses on immediate application to solve problems rather than developing broader theories. The results of action research are used directly by teachers and administrators to improve situations rather than generalizing to wider populations.
Problem Solving in Career Counselling (in Educational Settings)Syed Ali Roshan
10 slides•103 views
This document outlines problem solving as a career counseling method. It discusses the history and theoretical background of problem solving approaches. The method presentation involves 6 steps: defining the problem, generating solutions, evaluating solutions, selecting the best solution, planning implementation, and evaluating/revising the plan. Problem solving has been integrated into psycho-educational programs to increase career education effectiveness by developing self-knowledge, problem solving, and conflict management skills. The method has advantages like applicability to various contexts but also disadvantages like potential inefficiency if used in isolation without other techniques.
Meaning, definitions & need of educational research.Neha Deo
21 slides•7.4K views
To understand the meaning & nature of research, one must study the different definitions of research. In this presentation, definitions of research & educational research are given. From the definitions important characteristics of the research are listed & need of the educational research is also given.
The document summarizes research on ADHD and student achievement. It discusses how students with ADHD often have lower academic achievement on standardized tests compared to students without ADHD. The purpose is to examine if students without ADHD score higher. Early interventions are important to help students with ADHD be more successful in school and decrease negative symptoms. Several studies found poor academic performance in children with ADHD versus typically developing peers. In conclusion, ADHD appears in early ages and affects elementary test scores, putting students with ADHD at a disadvantage.
The document summarizes an elective course on occupational therapy offered at East Carolina University. It discusses the important outcomes of the course, including giving students a broader awareness of occupational therapy and helping some decide to pursue it as a career. It describes the textbook and online course components, which included recorded lectures, assignments applying the readings, and discussion boards. Student feedback showed the course helped students learn about unfamiliar areas of OT and most were glad they took the course to explore the profession.
This document outlines action research, including its definition, advantages, 4 steps, and threats to validity. Action research is conducted by educators to solve local problems. Its advantages include being done by anyone in any school to investigate problems and improve practice. The 4 steps are: 1) identifying the research question, 2) gathering information through methods like observations and interviews, 3) analyzing and interpreting the data, and 4) developing an action plan based on findings. Threats to validity include data collector bias and limited generalizability.
This document discusses three types of research methods: survey research, correlation research, and causal-comparative research. Survey research involves collecting data from a sample population at one or more points in time to describe characteristics. Correlation research investigates relationships between two variables to help explain behaviors or predict outcomes. Causal-comparative research attempts to determine the causes or consequences of existing differences between groups by comparing them. Examples of research objectives and questions are provided for each method.
Evaluating Revalidation: Lessons from the Evaluation of Complex Interventions IAMRAreval2015
26 slides•432 views
This document discusses key considerations for evaluating complex interventions like revalidation of physicians. It makes three main points:
1. Revalidation involves complex interactions that are nonlinear and context-dependent, so evaluations must account for these complexities. Randomized trials may not be possible.
2. Evaluations should have both formative and summative components to support learning and improvement, as well as assess merit and worth. Longitudinal, multilevel designs can help link processes to outcomes over time.
3. Evaluations must develop a clear theory of change and understand how different elements of revalidation interact and impact outcomes like quality of care. Stakeholder engagement and mixed methods can provide a more comprehensive understanding.
TSL3133 Topic 12 Quantitative Data AnalysisYee Bee Choo
14 slides•275 views
This document discusses descriptive statistics and how it can be used to summarize quantitative data from educational research. Descriptive statistics presents data using measures like percentages, frequencies, means, standard deviations, and graphs/charts. These summaries provide powerful overviews that allow comparisons across groups. Specific measures mentioned include the mode, median, mean, range, variance, and standard deviation. Examples are given of how descriptive statistics could be used to summarize student performance data through tables, line graphs, bar diagrams and pie charts. The document concludes with examples of surveys and tests where descriptive statistics measures could analyze and present the results.
Action research aims to solve practical problems through applying scientific knowledge. It originated from Kurt Lewin in the 1940s. The researcher and practitioner are usually the same person. There are four types: individual teacher, collaborative, school-wide, and district-wide research. The process involves identifying a problem, collecting and analyzing data, taking action, and evaluating results. The goal is solving classroom issues rather than generalizable scientific findings.
The document introduces the Integrated Functional Behavior Assessment Protocol (IFBAP), which provides a standard process for conducting functional analyses of problem behaviors in children with deafblindness or other severe disabilities. The IFBAP was developed with funding from the US Department of Education. It is based on the principles that problem behaviors serve functions like obtaining attention or rewards, and that assessment should drive behavioral programming to reduce problem behaviors and teach skills. The IFBAP provides guidance on assessing multiple contexts, targets, behaviors, and factors to develop individualized programming recommendations.
Before conducting research,in any field, researcher must understand the different basic concepts used in the Research Methodology.In this presentation, objectives, Need, Significance, Assumption & Hypothesis, these five concepts are considered.
Action research is a practical approach to improving professional practices through a cyclical process of identifying problems, planning and implementing solutions, observing the results, and reflecting on lessons learned. It aims to gather evidence to address specific problems in the settings where research is conducted. The document outlines the objectives, steps, and limitations of action research, noting that it involves careful monitoring of planned changes, collaboration, and use of both quantitative and qualitative methods to draw conclusions and modify practices.
Lesson 28 drawing logical conclusions from research findingsmjlobetos
11 slides•15K views
This document provides guidance on writing effective conclusions for research findings. It discusses that conclusions represent inferences drawn from study findings and should not contain measurements. It also outlines strategies for writing conclusions, such as ensuring they are intertwined with the introduction, draw inferences from findings, and specifically answer any problems stated. The document recommends conclusions be clear, concise, original, and accurate without introducing new information.
This study investigated the influence of exercise and study time on college students' academic coping strategies. Seventeen undergraduate students reported their weekly exercise and study hours, then completed a survey measuring coping abilities. Results found no significant main effects of exercise or study time on coping scores, and no significant interaction between exercise and study time. While exercise did not correlate with coping strategies in this study, it confirmed that individuals use various coping methods for academics. The study could be improved with a larger, more diverse sample size and alternative independent variables.
Action research is a process where teachers systematically examine their own practices to improve student learning and the classroom environment. It involves identifying an issue, developing a plan to address it, implementing changes, collecting data, analyzing the results, and iterating the process as needed. Benefits include improved teaching practices and collaboration between teachers. Limitations can include lack of time, research skills, and institutional support.
Characteristics of a researcher,Ethical considerations & areas of Educational...Neha Deo
12 slides•394 views
When any person wants to conduct research, she/he should possess some specific characteristics. The researcher must follow certain ethics. These points are considered in this presentation. Apart from that different areas for Educational research are also given in this presentation.
The document summarizes research on lecturers' perceptions of student evaluations. It discusses findings from questionnaires and interviews at three New Zealand institutions. Key findings include: 1) Most lecturers agreed that students can provide meaningful feedback, though some had reservations. 2) Lecturers with more student-centered teaching beliefs were more likely to engage with feedback. 3) Factors like timing of evaluations and their use in promotions influenced willingness to engage with feedback.
This document outlines the key aspects of action research in education. It defines action research as a systematic process conducted by teachers to gather information and improve their educational setting, teaching practices, and student learning. The document then discusses several distinguishing features of action research, including that it is participatory, contextual, aims to enact change, and involves a cyclical process of planning, acting, observing, and reflecting. Finally, the document provides an overview of common action research procedures and methods, such as identifying a problem, collecting and analyzing various forms of qualitative and quantitative data, and triangulating findings.
This document provides summaries of different research study designs by briefly describing examples of each design type. The designs included are: experimental, correlational, survey, grounded theory, ethnographic, narrative research, mixed methods, and action research. For each example a few key details are given such as the research topic, methodology used, and findings or purpose of the study to illustrate how it fits the particular design classification.
This study investigated the effectiveness of an eclectic framework developed by Ikiugu for combining theoretical conceptual practice models to guide clinical decision-making. 6 occupational therapists participated in a pre-test, intervention teaching the framework, and post-test. Scores on a measure of ability to combine models showed mostly moderate to large improvements, though small sample size limited significance. Qualitatively, participants reported feeling more confident in applying theory and combining models after learning the framework. The study provides preliminary support for the framework as a method to help therapists systematically integrate theory into practice. However, larger samples are needed.
Research is a systematic process of discovering new knowledge or truth. It involves identifying a problem, reviewing existing literature, collecting and analyzing data, and reporting findings. The goals of research include gaining new insights, accurately describing phenomena, determining relationships between variables, and testing hypotheses. Research can be basic/pure or applied, and uses quantitative, qualitative, descriptive, exploratory or causal methodologies. Research is important for advancing knowledge and solving practical problems across many fields.
Action research is a form of applied research that aims to empower people through a process of constructing and using knowledge. It involves practitioners systematically examining their own practices to improve conditions. Participatory action research specifically seeks to empower vulnerable groups through generating knowledge and action. The process involves identifying issues, collecting and interpreting data, acting on evidence, and evaluating results in continuous cycles of self-reflection. Outcome research assesses the end results of healthcare to develop evidence-based practices and improve services.
A study on common factors between critical thinking and religious education.pdfApril Smith
6 slides•7 views
This document summarizes research on common factors between critical thinking and religious education. It finds that both aim to search for truth, require precise vision, prevent bias, encourage flexibility and tolerance, promote independence, rely on clear judgment, ensure fairness, and require patience and hard work. A hybrid approach integrating critical thinking and religious education could help people in these areas. The document reviews several studies showing benefits of critical thinking skills and religious education on their own, and argues their combination can further help learning.
Basic research aims to develop or enhance theory without considering immediate practical applications. It involves collecting and analyzing data to test hypotheses and advance scientific understanding, even if the results have no obvious commercial or practical benefits. Some key points about basic research include:
- It increases fundamental knowledge and understanding without direct commercial objectives.
- Findings may not be immediately useful but often lay the groundwork for applied research and new technologies.
- It is primarily conducted by universities and seeks to explain phenomena rather than solve practical problems.
- The goal is explanatory research to generate new ideas and theories about how the world works.
Effects of Multiple Intellgences on Academic EducationQuinn Collor
10 slides•1.1K views
This paper reviews Critical studies on the effects of Multiple Intelligences on Academic Education. Based on the critically acclaimed work of Educational Theorist Howard Gardner.
This document discusses three types of research methods: survey research, correlation research, and causal-comparative research. Survey research involves collecting data from a sample population at one or more points in time to describe characteristics. Correlation research investigates relationships between two variables to help explain behaviors or predict outcomes. Causal-comparative research attempts to determine the causes or consequences of existing differences between groups by comparing them. Examples of research objectives and questions are provided for each method.
Evaluating Revalidation: Lessons from the Evaluation of Complex Interventions IAMRAreval2015
26 slides•432 views
This document discusses key considerations for evaluating complex interventions like revalidation of physicians. It makes three main points:
1. Revalidation involves complex interactions that are nonlinear and context-dependent, so evaluations must account for these complexities. Randomized trials may not be possible.
2. Evaluations should have both formative and summative components to support learning and improvement, as well as assess merit and worth. Longitudinal, multilevel designs can help link processes to outcomes over time.
3. Evaluations must develop a clear theory of change and understand how different elements of revalidation interact and impact outcomes like quality of care. Stakeholder engagement and mixed methods can provide a more comprehensive understanding.
TSL3133 Topic 12 Quantitative Data AnalysisYee Bee Choo
14 slides•275 views
This document discusses descriptive statistics and how it can be used to summarize quantitative data from educational research. Descriptive statistics presents data using measures like percentages, frequencies, means, standard deviations, and graphs/charts. These summaries provide powerful overviews that allow comparisons across groups. Specific measures mentioned include the mode, median, mean, range, variance, and standard deviation. Examples are given of how descriptive statistics could be used to summarize student performance data through tables, line graphs, bar diagrams and pie charts. The document concludes with examples of surveys and tests where descriptive statistics measures could analyze and present the results.
Action research aims to solve practical problems through applying scientific knowledge. It originated from Kurt Lewin in the 1940s. The researcher and practitioner are usually the same person. There are four types: individual teacher, collaborative, school-wide, and district-wide research. The process involves identifying a problem, collecting and analyzing data, taking action, and evaluating results. The goal is solving classroom issues rather than generalizable scientific findings.
The document introduces the Integrated Functional Behavior Assessment Protocol (IFBAP), which provides a standard process for conducting functional analyses of problem behaviors in children with deafblindness or other severe disabilities. The IFBAP was developed with funding from the US Department of Education. It is based on the principles that problem behaviors serve functions like obtaining attention or rewards, and that assessment should drive behavioral programming to reduce problem behaviors and teach skills. The IFBAP provides guidance on assessing multiple contexts, targets, behaviors, and factors to develop individualized programming recommendations.
Before conducting research,in any field, researcher must understand the different basic concepts used in the Research Methodology.In this presentation, objectives, Need, Significance, Assumption & Hypothesis, these five concepts are considered.
Action research is a practical approach to improving professional practices through a cyclical process of identifying problems, planning and implementing solutions, observing the results, and reflecting on lessons learned. It aims to gather evidence to address specific problems in the settings where research is conducted. The document outlines the objectives, steps, and limitations of action research, noting that it involves careful monitoring of planned changes, collaboration, and use of both quantitative and qualitative methods to draw conclusions and modify practices.
Lesson 28 drawing logical conclusions from research findingsmjlobetos
11 slides•15K views
This document provides guidance on writing effective conclusions for research findings. It discusses that conclusions represent inferences drawn from study findings and should not contain measurements. It also outlines strategies for writing conclusions, such as ensuring they are intertwined with the introduction, draw inferences from findings, and specifically answer any problems stated. The document recommends conclusions be clear, concise, original, and accurate without introducing new information.
This study investigated the influence of exercise and study time on college students' academic coping strategies. Seventeen undergraduate students reported their weekly exercise and study hours, then completed a survey measuring coping abilities. Results found no significant main effects of exercise or study time on coping scores, and no significant interaction between exercise and study time. While exercise did not correlate with coping strategies in this study, it confirmed that individuals use various coping methods for academics. The study could be improved with a larger, more diverse sample size and alternative independent variables.
Action research is a process where teachers systematically examine their own practices to improve student learning and the classroom environment. It involves identifying an issue, developing a plan to address it, implementing changes, collecting data, analyzing the results, and iterating the process as needed. Benefits include improved teaching practices and collaboration between teachers. Limitations can include lack of time, research skills, and institutional support.
Characteristics of a researcher,Ethical considerations & areas of Educational...Neha Deo
12 slides•394 views
When any person wants to conduct research, she/he should possess some specific characteristics. The researcher must follow certain ethics. These points are considered in this presentation. Apart from that different areas for Educational research are also given in this presentation.
The document summarizes research on lecturers' perceptions of student evaluations. It discusses findings from questionnaires and interviews at three New Zealand institutions. Key findings include: 1) Most lecturers agreed that students can provide meaningful feedback, though some had reservations. 2) Lecturers with more student-centered teaching beliefs were more likely to engage with feedback. 3) Factors like timing of evaluations and their use in promotions influenced willingness to engage with feedback.
This document outlines the key aspects of action research in education. It defines action research as a systematic process conducted by teachers to gather information and improve their educational setting, teaching practices, and student learning. The document then discusses several distinguishing features of action research, including that it is participatory, contextual, aims to enact change, and involves a cyclical process of planning, acting, observing, and reflecting. Finally, the document provides an overview of common action research procedures and methods, such as identifying a problem, collecting and analyzing various forms of qualitative and quantitative data, and triangulating findings.
This document provides summaries of different research study designs by briefly describing examples of each design type. The designs included are: experimental, correlational, survey, grounded theory, ethnographic, narrative research, mixed methods, and action research. For each example a few key details are given such as the research topic, methodology used, and findings or purpose of the study to illustrate how it fits the particular design classification.
This study investigated the effectiveness of an eclectic framework developed by Ikiugu for combining theoretical conceptual practice models to guide clinical decision-making. 6 occupational therapists participated in a pre-test, intervention teaching the framework, and post-test. Scores on a measure of ability to combine models showed mostly moderate to large improvements, though small sample size limited significance. Qualitatively, participants reported feeling more confident in applying theory and combining models after learning the framework. The study provides preliminary support for the framework as a method to help therapists systematically integrate theory into practice. However, larger samples are needed.
Research is a systematic process of discovering new knowledge or truth. It involves identifying a problem, reviewing existing literature, collecting and analyzing data, and reporting findings. The goals of research include gaining new insights, accurately describing phenomena, determining relationships between variables, and testing hypotheses. Research can be basic/pure or applied, and uses quantitative, qualitative, descriptive, exploratory or causal methodologies. Research is important for advancing knowledge and solving practical problems across many fields.
Action research is a form of applied research that aims to empower people through a process of constructing and using knowledge. It involves practitioners systematically examining their own practices to improve conditions. Participatory action research specifically seeks to empower vulnerable groups through generating knowledge and action. The process involves identifying issues, collecting and interpreting data, acting on evidence, and evaluating results in continuous cycles of self-reflection. Outcome research assesses the end results of healthcare to develop evidence-based practices and improve services.
A study on common factors between critical thinking and religious education.pdfApril Smith
This document summarizes research on common factors between critical thinking and religious education. It finds that both aim to search for truth, require precise vision, prevent bias, encourage flexibility and tolerance, promote independence, rely on clear judgment, ensure fairness, and require patience and hard work. A hybrid approach integrating critical thinking and religious education could help people in these areas. The document reviews several studies showing benefits of critical thinking skills and religious education on their own, and argues their combination can further help learning.
Basic research aims to develop or enhance theory without considering immediate practical applications. It involves collecting and analyzing data to test hypotheses and advance scientific understanding, even if the results have no obvious commercial or practical benefits. Some key points about basic research include:
- It increases fundamental knowledge and understanding without direct commercial objectives.
- Findings may not be immediately useful but often lay the groundwork for applied research and new technologies.
- It is primarily conducted by universities and seeks to explain phenomena rather than solve practical problems.
- The goal is explanatory research to generate new ideas and theories about how the world works.
Effects of Multiple Intellgences on Academic EducationQuinn Collor
This paper reviews Critical studies on the effects of Multiple Intelligences on Academic Education. Based on the critically acclaimed work of Educational Theorist Howard Gardner.
Research Paradigms.htmlThe term ‘research’ is commonly underst.docxaudeleypearl
Research Paradigms.html
The term ‘research’ is commonly understood to denote a systematic process of discovering more about a topic, using methods that are transparent and publicly defensible. Within this broad definition lie different strands of activity. A key distinction in education and development is between scholarly research and research conducted for consultancy or monitoring and evaluation purposes. Monitoring and evaluation (sometimes referred to as ‘M & E’) is chiefly used in relation to specific projects and usually focuses on the effectiveness of the project in relation to specified (and often narrow) goals. It is unlikely to be asking deeper questions or engaging with the debates in academic literature that scholarly research tends to be concerned with.
Measurement and indicators 1
TEGINT Project
The TEGINT project (Transforming Education for Girls in Nigeria and Tanzania) sought to address gender inequalities in schools and communities through three interventions: the establishment of ‘girls’ clubs’ in schools, of school committees and of participatory, gender-sensitive teaching methodologies. The monitoring and evaluation process, run at regular points during the programme, sought to discover the impact on particular outcomes such as girls’ enrolment and progression. Data collected annually for M & E included gender-disaggregated figures for enrolment by class, exam entry, exam passes, drop-outs, attendance, numbers of teachers and numbers on the school management committees. However, broader research conducted at the start and the end of the project, in conjunction with university partners, attempted to address more complex issues such as the relationships between girls’ club membership, community attitudes and girls’ empowerment (ActionAid 2012).
Epistemological and political positions; decolonizing methodologies; different research traditions
As a researcher, it is always important to consider which assumptions and political positions underpin one’s work. No research (and no researcher) is completely objective and without a position, no matter how unbiased they believe themselves to be. These are particularly important considerations when working on education and development. If the researcher is from a different educational background to that which is being researched, it may lead to some comparative bias, particularly if the context being researched is a developing country. Researchers may become overwhelmed with the deficiencies of the research context and be blind to positive aspects that may have been undervalued or lacking in their own education. It is also important to note that some methodological approaches explicitly and intentionally contain political positions and aims (e.g. feminist research).
A number of theoretical and methodological developments since the 1970s have aimed to reveal and break down hidden assumptions in research. Postcolonial perspectives seek to question the extent to which certain educationa ...
Using programme theory for evaluation of complex health interventions at dist...Prashanth N S
In this presentation, we explain the process through which a realist evaluation could be conducted on complex interventions through the building and refining of programme theories of these interventions.
Day 2 keynote: Sanjeev Sridharan, University of Toronto: “Research and evaluation in global health policy processes”
Workshop on Approaches and Methods for Policy Process Research, co-sponsored by the CGIAR Research Programs on Policies, Institutions and Markets (PIM) and Agriculture for Nutrition and Health (A4NH) at IFPRI-Washington DC, November 18-20, 2013.
This document summarizes a presentation given by Matt Beavis on a research study examining how staff in a large UK mental health trust learn from serious case reviews of incidents involving harm to children. Through interviews with 27 direct care staff and managers, the study found low awareness of serious case reviews and an inability to demonstrate learning from them. However, staff felt the trust tries to be a learning organization, and appreciated being involved in the research. The presentation outlines barriers to organizational and individual learning, and recommends increasing early staff involvement, more creative learning approaches, and focusing on embedding learning in organizational culture. The overarching goal is improving how the trust enables staff to learn lessons that improve safeguarding practices.
RESEARCH METHODOLOGY ( NTA 7)_EAE_EBE (2) (1).pptxGodlistenNyari
Research is a systematic process of discovery and advancement of human knowledge’ (Gratton & Jones, 2009, p.4).
According to Theodorson and Theodorson (1969) research refers to any honest attempt to study a problem systematically or to add to man’s knowledge of a problem.
According to Saunders et al. (2007) research is something that people undertake to find out things in a systematic way, thereby increasing their knowledge
According to Waltz and Bansell (1981). Research is a systematic, formal, rigorous and precise process employed to gain solutions to problems or to discover and interpret new facts and relationships.
According to Kothari (2006). Research is a pursuit of trust with the help of study, observation, comparison and experiment, the search for knowledge through objective and systematic method of finding solutions to a problem.
According to Payton (1979). Research is the process of looking for a specific question in an organized, objective, reliable way.
Kerlinger (1873). Research is a systematic controlled, empirical and critical investigation of hypothetical propositions about the presumed relations among natural phenomena.
Ethical issues in research presentation.pptxgororotich
Ethical issues in educational research encompass considerations around informed consent, privacy/confidentiality, and participant protection. Key ethical issues occur during research design, conduct, and dissemination. Researchers must obtain informed consent, protect privacy of sensitive data, minimize potential harms, and ensure research benefits the educational community. Upholding ethical guidelines is important for responsible and impactful educational research.
Trends and methods of educational research in the ukmemogreat
The document discusses trends and methods of educational research used in the UK. It covers quantitative and qualitative research approaches, as well as mixed-method research. It also discusses action research and design-based research as participatory research approaches that involve collaboration. Design-based research aims to improve educational practice through iterative design, while also generating design principles and learning theories.
The World Testifies Of Data And Our Understanding Of It EssaySandy Harwell
The document discusses qualitative research methods. It defines qualitative research as exploring and describing phenomena through subjective and inductive strategies. Some key points made include:
- Qualitative research aims to answer questions about why and how things occur.
- There are three main purposes: exploratory, explanatory, and descriptive. Exploratory research discovers patterns in phenomena, while explanatory research identifies relationships shaping phenomena and descriptive research documents phenomena of interest.
- Qualitative research relies on non-experimental and phenomenological approaches to collect data through open-ended questions and observations.
Research methods a critical review1AimsTo .docxverad6
The document discusses and compares different research methods and methodologies. It explores qualitative methods like grounded theory and ethnography. Grounded theory involves deriving theories from participant feedback through simultaneous data collection and analysis. Ethnography requires researchers to immerse themselves in a culture for an extended period to understand practices from an insider perspective. The document also examines quantitative methods like surveys and interviews. It provides examples of research projects and discusses limitations and tensions researchers may face. Additionally, it covers ontological and epistemological approaches, comparing positivist and constructivist paradigms.
V1 researchSEND, University of Wolverhampton, 23 June 2018Gary Jones
Dr. Gary Jones presented on evidence-based practice in education. He defined evidence-based practice and discussed common misconceptions. He outlined tools like PICO and SPICE for framing questions to guide evidence searches. Jones also covered acquiring, appraising, and aggregating evidence to inform decisions. He argued that evidence-based practice should prioritize ethical leadership, involve multiple stakeholders, and apply principles to all aspects of a school to truly impact outcomes. While challenges exist, reasonably straightforward techniques can help make decisions more evidence-based.
The document discusses an illuminative/responsive approach to evaluating an English as a foreign language (EFL) learning support program (LSP) in Greece. It describes a 4-step evaluation process: 1) Preparing stakeholders, 2) Identifying the program setting, 3) Sharing, observing, and seeking feedback, and 4) Reviewing, reflecting, and remedying issues. The evaluation aims to foster autonomous learning and involvement of all stakeholders at each step. It is argued that this participatory, formative approach can help programs improve, build ownership among stakeholders, and make evaluation less opposed in the Greek educational system.
Responsive evaluation offers an alternative approach to evaluation that focuses on engaging stakeholders in the evaluation process. It aims to generate qualitative evidence about program effectiveness by deriving criteria from the perspectives of various stakeholders, including policymakers, managers, practitioners, community members, and target groups. Through dialogue and deliberation, stakeholders become equal partners in formulating evaluation questions, selecting participants, and interpreting findings. The goal is not consensus but rather a shared understanding of different viewpoints. Validation strategies include gathering stakeholder feedback, triangulating data sources and methods, and documenting the evaluation process to ensure trustworthiness. The article argues that responsive evaluation is well-suited for health promotion work by incorporating diverse stakeholder values and community perspectives.
Online discussions with classmates are fruitful: Fostering postgraduate colla...Ben Harris-Roxas
Heywood, A., & Harris-Roxas, B. (2020, November 19). “Online discussions with classmates are fruitful”: Fostering postgraduate collaborative learning using an assessable asynchronous peer-led discussion forum. UNSW 2020 Learning and Teaching Forum – “Learning without limits: Leading the change”, Sydney.
Use of translation apps and websites in health care settingsBen Harris-Roxas
The convenience and immediacy of translation apps is appealing, however this needs to be balanced against the need for quality translation. This study provides the amongst the first empirical evidence internationally on the extent and nature of the use of translation apps in health care settings. The findings may inform guideline development and policy responses.
Use of translation apps and websites in health care settingsBen Harris-Roxas
Ben Harris-Roxas,1,2 Lisa Woodland,3,1 Joanne Corcoran,3 Jane Lloyd,1,4 Mark Harris,1 Rachael Kearns,1,2 Iqbal Hasan1
Australasian Association for Academic Primary Health Care ConferenceAdelaide, 12-13 July 2019
Health impact assessments of health sector proposalsBen Harris-Roxas
This document summarizes a review of health impact assessments (HIAs) conducted on health sector proposals. The review identified 14 HIAs from Australia, Korea, and the UK that assessed various health services, plans, and policies. The HIAs used a variety of evidence sources and methods. Most assessments were of projects or programs rather than policies. The quality of reporting varied and there is opportunity to strengthen documentation of scoping and monitoring/evaluation steps. While HIAs have been conducted in developed countries, there is limited evidence of their use to assess clinical services plans within the health sector.
Health impact assessment as a tool to promote urban health the experience in...Ben Harris-Roxas
This document summarizes Ben Harris-Roxas' presentation on the development and use of health impact assessment (HIA) tools in Australia over the past 15 years. Some key points:
1. HIA was introduced in Australia in the 1990s/2000s and has been used in over 45 assessments, primarily by local governments and health agencies, to evaluate potential health impacts of projects and policies.
2. A case study of the Green Square urban development project in Sydney is described, where an HIA examined impacts on housing, transportation, air quality, and especially child health. Recommendations focused on schools, recreation facilities, and child-friendly design.
3. Lessons from 15 years of
Using the Patient Activation Measure to improve quality of care for patients ...Ben Harris-Roxas
The document summarizes research using the Patient Activation Measure (PAM) to improve quality of care for patients with chronic conditions. The PAM gauges a patient's knowledge, skills, and confidence in managing their own health. The research included a literature review finding the PAM has been used to tailor care and assess risk profiles. A retrospective audit in one local health district found the PAM score improved after a pulmonary rehabilitation program. A pilot study is currently testing using the PAM in clinical practice to improve quality of care. Barriers and facilitators to implementing the PAM as a tailoring tool are being examined.
This document summarizes a health impact assessment of the Green Square urban renewal project in Sydney, Australia. Green Square is a high-density brownfield development that will eventually be home to 61,000 residents and 21,000 jobs. The assessment focuses on potential impacts to children, including exposure to traffic, air pollution, and lack of green space. It recommends urgent investment in schools, recreational facilities, and infrastructure to promote safe walking and cycling. Maintaining building codes to allow space for children's play, bikes, and outdoor areas is also suggested.
Equity focused health impact assessment - The role of the health system in re...Ben Harris-Roxas
This document provides an overview of equity focused health impact assessments (EFHIAs), including examples of EFHIAs that have been conducted, what factors contribute to their effectiveness, and opportunities and challenges for their use within health systems. EFHIAs aim to consider how policies and programs may differentially impact health equity and identify determinants of health inequities. Structured EFHIA processes, identifying assumptions, transparency around trade-offs, and aligning with implementation can help ensure their effectiveness, while challenges include additional complexity, lack of shared understanding and organizational commitment. The role of EFHIA in health systems was discussed.
Health Impact Assessment - INPES Journées de la prévention 2015Ben Harris-Roxas
This document provides an overview of health impact assessment (HIA). It discusses the evolution of HIA from environmental assessments in the 1950s-1970s to the current focus on health equity. HIAs can be mandated, used for decision support, or led by advocacy groups/communities. The document outlines the key components of HIAs and common health impacts assessed. It also discusses challenges like the perception that HIAs are expensive and time-consuming, and notes they can be done rapidly. The document concludes with resources for further information on HIA practice.
This document provides an overview of health impact assessment (HIA). It discusses:
- The background and experience of the author in conducting HIAs
- Why health matters and the environmental and social determinants of health
- What HIA is and when it is conducted
- The typical steps involved in an HIA including screening, scoping, assessment and recommendations
- Examples of different types of projects and policies that HIAs have been conducted for
- How HIA relates to and incorporates environmental health issues
- Resources available for learning more about HIA
Effectiveness of HIAs in Australia and New ZealandBen Harris-Roxas
This study examined the effectiveness of health impact assessments (HIAs) conducted in Australia and New Zealand between 2005 and 2009. The researchers identified 55 HIAs and surveyed those involved to assess the level of effectiveness. They also conducted 11 in-depth case studies. The study found that 89% of HIAs were directly or generally effective in changing decisions, with factors like support from decision-makers, community engagement, and timely involvement increasing effectiveness. While no single factor guarantees success, the study demonstrates that HIAs can be an effective tool to incorporate health considerations into public policy decisions.
Using social media for messaging about healthy eating and active livingBen Harris-Roxas
This document provides an overview of using social media for messaging about healthy eating and active living. It discusses what social media is, trends in social media use in Australia and internationally, and examples of effective social media strategies. Key points include:
- Social media allows for user-generated content and sharing on platforms like Facebook, YouTube, and Twitter. Usage in Australia is high, especially among younger age groups.
- Effective social media strategies for health promotion include collaborative projects, organizational websites, Twitter, blogs, YouTube videos, and Facebook pages. Case studies show benefits of integration with other campaigns.
- Challenges include evaluating impact, as well as reaching priority groups like rural communities, older adults, people with disabilities, and
The document provides an overview of health impact assessment (HIA) and discusses Ben Harris-Roxas' experience conducting HIAs since 2003, how HIA fits within environmental health and the social determinants of health, the typical steps involved in an HIA, and examples of different types of proposals and policies that HIAs have been applied to.
The document discusses social media and its role as either a friend or foe. It covers the major social media platforms like Facebook and Twitter and their use among different age groups. While social media enables two-way communication, broadcast media still has relevance. Both opportunities and risks exist with social media, including amplification and shifting relationships. Government agencies can effectively use social media depending on their approach, such as internal communication, broadcast, or broader engagement.
Health Impact Assessment: A triumph over common sense?Ben Harris-Roxas
This document summarizes a presentation on evaluating the effectiveness of health impact assessments (HIAs). It discusses how perceptions of HIA effectiveness are complex and can be affected by narrative fallacy and creeping determinism. It advocates for prospective evaluations of HIAs that collect data before, during, and after to address these issues, and comparative studies of similar proposals with and without HIAs. HIAs of health proposals are particularly important to demonstrate their ability to change understanding within the health sector and promote health in all policies. While HIA recommendations may seem like common sense, common sense is not always common and HIA can help address issues in a timely manner.
Popular or political? Trade-offs in health impact assessentBen Harris-Roxas
This document summarizes findings from the first phase of an Australia-New Zealand study on the effectiveness of health impact assessments (HIAs). It presents data on levels of community involvement and controversy in HIAs. The data show that most HIAs involved community participation but also faced some level of controversy. HIAs that involved communities and faced higher controversy were less likely to directly influence decisions but more likely to raise general awareness. The relationship between participation, controversy and effectiveness is complex with many trade-offs to consider. An example from Lithgow, Australia is provided to illustrate these trade-offs.
Health Impact Assessment: Fit for more than one purposeBen Harris-Roxas
This document discusses typologies and theories of health impact assessment (HIA). It presents a typology that categorizes HIAs into four forms based on their purpose: mandated, decision support, advocacy, and community-led. It also discusses three different types of learning that can result from HIAs - technical, conceptual, and social. The document emphasizes that the purpose and potential learning outcomes should be considered when evaluating the effectiveness of HIAs.
HIA emerged from the fields of environmental health, the social view of health, and a focus on health equity. It combines procedures, methods and tools to assess potential health impacts of policies, programs and projects. Key milestones in the development of HIA included environmental disasters in the 1950s-60s that highlighted links between the environment and health, and reports from the 1970s-80s that emphasized social and environmental determinants of health and health inequities. Formal HIA practice arose in the 1990s and 2000s with the goal of considering health impacts and equity earlier in the decision making process.
Health impact assessment (HIA) is a combination of procedures, methods and tools to judge the potential health effects of policies, programs or projects on a population. An HIA identifies how proposals affect health and wellbeing, who they affect, and what can be done to maximize benefits and minimize harms. The steps of an HIA include screening, scoping, identification, assessment, recommendations, and evaluation/monitoring. An HIA considers both intended and unintended effects and how impacts are distributed across populations based on factors like age, gender, socioeconomic status and location.
Health Impact Assessment: An overview of practice worldwideBen Harris-Roxas
Health impact assessment (HIA) originated from environmental health, social views of health, and health equity. HIA has evolved differently than environmental impact assessment, expanding to include strategic assessment processes. There are several approaches countries take to institutionalizing HIA, including requiring health be considered in environmental impact assessments, requiring stand-alone HIAs for certain project types, and giving health authorities rights to conduct HIAs when deemed necessary. HIA practice has spread worldwide over the past several decades.
TRACHEOESOPHAGEAL FISTULA.pdf FOR NURSING STUDENTSKIRAN KARETHA
Tracheoesophageal fistula is an abnormal connection between the
trachea and esophagus.
It occurs in 1 in 3,500 births
Type A (esophageal atresia)
Type B (esophageal atresia with proximal fistula)
Type C (esophageal atresia with Distal fistula)
Type D (esophageal atresia with proximal and distal fistula)
Type E (H- typed fistula)
echinocandins case presentation.dr ANKUSH GOYAL GMC PATIALADr Ankush goyal
Echinocandins: A Comprehensive Overview
Introduction
Echinocandins are a class of antifungal agents that have gained significant prominence in the treatment of invasive fungal infections, particularly those caused by Candida and Aspergillus species. They are considered second-line or first-line treatment options in cases of azole-resistant fungal infections. This document provides an in-depth discussion of echinocandins, including their chemical structure, mechanism of action, pharmacokinetics, spectrum of activity, clinical applications, resistance mechanisms, adverse effects, and future perspectives.
Historical Background
Echinocandins were first discovered in the late 20th century when researchers were exploring natural antifungal compounds derived from fungi and other microorganisms. The first echinocandin, pneumocandin B0, was isolated from Glarea lozoyensis. Further modifications led to the development of caspofungin, micafungin, and anidulafungin, which are the three currently approved echinocandins for clinical use.
Chemical Structure
Echinocandins are cyclic lipopeptides composed of a large cyclic hexapeptide core linked to a long-chain fatty acid side group. This unique structure is crucial for their antifungal activity and their pharmacokinetic properties. The lipid tail enhances the compound's binding affinity to fungal cells, while the cyclic peptide core is responsible for inhibiting fungal cell wall synthesis.
Mechanism of Action
Echinocandins exert their antifungal effects by selectively inhibiting the enzyme (1→3)-β-D-glucan synthase, which is essential for the synthesis of β-glucan, a major component of the fungal cell wall. The inhibition of β-glucan synthesis results in cell wall weakening, osmotic instability, and ultimately fungal cell lysis. This mechanism makes echinocandins highly selective for fungi, as mammalian cells lack β-glucan.
Pharmacokinetics
Echinocandins are administered intravenously due to their poor oral bioavailability. The pharmacokinetic properties of caspofungin, micafungin, and anidulafungin vary slightly, but they share several common features:
Distribution: Echinocandins exhibit extensive tissue penetration, particularly in the liver, spleen, lungs, and kidneys. However, their penetration into the cerebrospinal fluid (CSF) is limited, making them less effective for central nervous system fungal infections.
Metabolism: Caspofungin undergoes hepatic metabolism through hydrolysis and N-acetylation, while micafungin is metabolized by the liver via arylsulfatase and catechol-O-methyltransferase. Anidulafungin undergoes spontaneous degradation in the plasma without significant hepatic metabolism.
Elimination: The elimination of echinocandins varies; caspofungin is excreted through both hepatic and renal routes, micafungin is eliminated hepatically, and anidulafungin is primarily excreted via fecal routes due to spontaneous degradation.
Half-life: Caspofungin has a half-life of approximately 9-
Let's Talk About It: Gynecologic Cancer (Calm Body, Calm Mind - Using Your Bo...RheannaRandazzo
Stress manifests in our thinking, emotions, and bodies. Recognizing those signs and building skills to address stress takes attention and effort. Cultivating skills to use your body as a tool to help you find calm and regain a sense of control can help you navigate moments of heightened anxiety. Join us on Wednesday, March 12th, to learn strategies for quieting your body and, thereby, calming your mind. Let’s Talk About It.
Learning Objectives:
1. Discuss free water clearance
2. Differentiate between diabetes insipidus and SIADH
3. Describe the control of extracellular fluid osmolarity and sodium concentration in terms of the osmoreceptor-ADH system and thirst mechanism
4. Describe the roles of Angiotensin II, Aldosterone, and salt appetite mechanism in the control of extracellular fluid osmolarity and sodium concentration
### **Acyclovir and Anti-Herpes Medications**
**Acyclovir** is an antiviral medication used to treat infections caused by herpes viruses, including:
- **Herpes simplex virus (HSV-1 & HSV-2)** – Causes cold sores and genital herpes.
- **Varicella-zoster virus (VZV)** – Causes chickenpox and shingles.
### **Mechanism of Action:**
Acyclovir works by inhibiting viral DNA replication. It is activated inside virus-infected cells, where it blocks viral enzymes, preventing the virus from multiplying.
### **Forms & Dosage:**
- **Oral (Tablets/Capsules/Liquid)** – Used for mild to moderate infections.
- **Topical (Cream/Ointment)** – For cold sores and mild skin infections.
- **Intravenous (IV)** – For severe infections like herpes encephalitis.
### **Other Anti-Herpes Medications:**
- **Valacyclovir (Valtrex)** – A prodrug of acyclovir with better absorption.
- **Famciclovir (Famvir)** – Another antiviral with a longer duration of action.
- **Penciclovir (Denavir)** – Used topically for herpes labialis (cold sores).
### **Uses:**
- Treats and manages outbreaks of herpes simplex.
- Reduces the severity and duration of symptoms.
- Used for long-term suppression to prevent recurrent infections.
- Helps in managing shingles and chickenpox.
### **Side Effects:**
- Nausea, vomiting, diarrhea.
- Headache, dizziness, fatigue.
- Rare: Kidney issues, allergic reactions.
### **Precautions:**
- Drink plenty of fluids to prevent kidney issues.
- Not a cure, but helps manage symptoms.
- Safe for most patients but should be used cautiously in people with kidney disease or weakened immune systems.
Prescribing for Heart Failure: A Guide for MBBS StudentsShivankan Kakkar
This SlideShare presentation provides a concise reference for MBBS students on prescription writing for heart failure. It covers key medications, treatment approaches, and clinical guidelines for effective management.
Growth and development milestone 7 months .pptxAbhishek Verma
Growth and developed milestone for a 7 months old children
Milestone 7 months
At seven months, your baby is becoming more active, curious, and expressive! Many can sit up without support, reach for toys, and even start rocking on their hands and knees, a sign that crawling is coming soon. Their grip is improving, so they enjoy grabbing, shaking, and banging objects together.
Socially, they recognize their name, respond to familiar voices, and may show separation anxiety when a parent leaves the room. They love interactive games like peekaboo and enjoy babbling sounds like “ba-ba” and “da-da.”
Solid foods are now a regular part of their diet, along with breast milk or formula. They may sleep 12–16 hours a day, including two or three naps.
Every baby develops at their own pace, so don’t worry if they’re not hitting every milestone at the same time as others. Enjoy this exciting stage of discovery and growth.
Discover the essential growth and development milestones of a 7-month-old baby. Learn about physical, cognitive, emotional, and social developments, including motor skills, sensory awareness, speech progress, and feeding habits. Get expert parenting tips, activities, and guidance to support your baby's healthy development. Stay informed with this comprehensive guide
Wondering what milestones your 7-month-old should be reaching? This expert guide covers key physical, cognitive, and social developments, from sitting up and babbling to improved
hand-eye coordination. Learn about feeding,
sleep patterns, and fun activities to support your baby's growth. Get top parenting tips and insights to ensure your little one thrives!
#pediatricnursing #Growthanddevelopment
#Growthanddevelopmentalmilestones
Growth and development ppt
Growth and development milestone slideshare ppt
**HIV Treatment: A Comprehensive Overview**
## Introduction
Human Immunodeficiency Virus (HIV) is a major global health challenge that affects millions of people. While there is no cure for HIV, advancements in medical research have led to effective treatment options that allow individuals with HIV to lead healthy lives. The primary treatment for HIV is antiretroviral therapy (ART), which helps to control the virus and prevent its progression to Acquired Immunodeficiency Syndrome (AIDS). This document explores the various aspects of HIV treatment, including its history, types of medications, effectiveness, side effects, challenges, and future developments.
## History of HIV Treatment
The history of HIV treatment dates back to the 1980s when the first cases of AIDS were identified. Researchers quickly began searching for treatments to combat the virus. In 1987, the first antiretroviral drug, zidovudine (AZT), was approved. While it provided some benefits, AZT had significant toxicity and limited long-term efficacy. Over time, scientists developed new classes of antiretroviral drugs, leading to the combination therapy approach, which has dramatically improved patient outcomes.
## Antiretroviral Therapy (ART)
### How ART Works
ART consists of a combination of drugs that target different stages of the HIV lifecycle. These medications reduce the viral load (the amount of HIV in the blood) to undetectable levels, thereby preventing the virus from weakening the immune system. ART also reduces the risk of HIV transmission to others.
### Classes of Antiretroviral Drugs
There are several classes of antiretroviral drugs, each working in different ways to inhibit the replication of HIV:
1. **Nucleoside Reverse Transcriptase Inhibitors (NRTIs)** - These drugs block reverse transcriptase, an enzyme HIV uses to convert its RNA into DNA. Examples include zidovudine (AZT), lamivudine (3TC), and tenofovir (TDF).
2. **Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)** - NNRTIs bind directly to reverse transcriptase and inhibit its function. Examples include efavirenz and nevirapine.
3. **Protease Inhibitors (PIs)** - These drugs prevent HIV from maturing and becoming infectious by inhibiting the protease enzyme. Examples include lopinavir and atazanavir.
4. **Integrase Strand Transfer Inhibitors (INSTIs)** - These drugs prevent HIV from integrating its genetic material into human DNA. Examples include raltegravir and dolutegravir.
5. **Entry Inhibitors** - These drugs prevent HIV from entering human cells. Examples include maraviroc (CCR5 antagonist) and enfuvirtide (fusion inhibitor).
6. **Pharmacokinetic Enhancers** - These drugs improve the effectiveness of other antiretroviral medications by increasing their concentration in the bloodstream. An example is ritonavir.
## Effectiveness of HIV Treatment
### Viral Suppression
When taken consistently, ART can reduce the viral load to undetectable levels. Studies have shown that individuals with u
Good Laboratory Practices (GLP) Ensuring Quality and Compliance.pptxDr. Smita Kumbhar
Good Laboratory Practices (GLP): Ensuring Quality and Compliance
Good Laboratory Practices (GLP) is a set of principles intended to ensure the quality, integrity, and reliability of non-clinical laboratory studies that support research and regulatory submissions. These guidelines are critical in the pharmaceutical, biotechnological, chemical, and environmental sectors, ensuring that laboratory-generated data are reproducible, credible, and internationally accepted.
GLP standards primarily apply to safety studies involving pharmaceuticals, pesticides, food additives, and industrial chemicals. Regulatory agencies, including the USFDA, EMA, and OECD, enforce GLP compliance to maintain scientific rigor and public safety.
USFDA GLP Regulations The U.S. Food and Drug Administration (USFDA) established Good Laboratory Practice regulations under 21 CFR Part 58. These regulations outline responsibilities for study directors, testing facilities, and personnel to maintain quality and integrity in non-clinical laboratory studies. The regulations cover various aspects, including study conduct, reporting, and archiving, ensuring consistency and accuracy in laboratory research.
Controlling the GLP Inspection Process
Regulatory authorities conduct inspections to verify GLP compliance. Laboratories must prepare for inspections by:
• Maintaining up-to-date documentation.
• Conducting internal audits.
• Ensuring personnel training and awareness.
• Implementing corrective actions for non-compliance.
Regulatory inspections typically assess laboratory infrastructure, personnel competence, study documentation, and adherence to protocols. Laboratories must demonstrate transparency and proactive quality control measures.
Documentation in GLP
Accurate and comprehensive documentation is crucial in GLP compliance. Key documentation elements include:
• Study protocols
• Standard operating procedures (SOPs)
• Raw data records
• Analytical reports
• Audit reports
• Equipment calibration records
• Archiving and retention policies
Proper documentation ensures traceability, accountability, and reliability in laboratory research.
Audit in GLP Compliance
Auditing is a critical component of GLP, ensuring adherence to established regulations and identifying areas for improvement. Audits can be internal (self-audit) or external (regulatory or third-party audits).
Goals of Laboratory Quality Audit
• Ensure compliance with GLP regulations.
• Identify gaps and areas for improvement.
• Validate data integrity and accuracy.
• Enhance operational efficiency.
• Prevent regulatory penalties and study disqualification.
Audit Tools in GLP
Laboratories use various audit tools to assess compliance, including:
• Checklists and self-assessments
• Internal quality audits
• Electronic data tracking systems
• Third-party inspections
• Root cause analysis
• Corrective and preventive action (CAPA) plans
Future of GLP Regulations
VENTILATORS.pptx FOR NURSING STUDENTS CREATED BY KIRAN KARETHAKIRAN KARETHA
VENTILATOR
Mechanical ventilation is a form of artificial respiration that uses a breathing machine to assist patients with breathing.
Mechanical ventilation is the use of a mechanical device to inflate and deflate the lungs.
A mechanical ventilation is a machine that generates a controlled flow of gas into a patient’s airways.
INDICATIONS
Acute lung injury
Apnea with respiratory arrest
COPD
Acute respiratory acidosis
Hypoxemia
hypercapnia
Classification of ventilators:
1. negative pressure ventilators: mechanical ventilators exert a negative pressure on the external chest. Decreasing the intrathoracic pressure during inspiration allows air to flow into the lung, filling its volume.
NEGATIVE PRESSURE VENTILATORS
1. Iron lung (drinker respirator tank)
2. body wrap and chest cuirass (tortoise shell)
POSITIVE PRESSURE VENTILATORS
1. pressure cycled ventilators
2. time cycled ventilators
3. volume cycled ventilators
4. non-invasive positive pressure ventilators
a) continuous positive airway pressure
b) bilevel positive airway pressure
Homology modelling and generation of 3D-structure of protein (G).pptxGarimaSingh204707
Homology modeling, also known as comparative modeling, is a computational method used to predict the three-dimensional (3D) structure of a protein based on its amino acid sequence. This technique relies on the principle that proteins with similar amino acid.
Artificial Intelligence in Medical Studies.pptxMahnoor Fatima
This presentation explores the integration of Artificial Intelligence (AI) in medical studies, focusing on its benefits, challenges, and ethical considerations. As AI continues to shape modern healthcare, understanding students’ perspectives is crucial in designing future medical education programs.
🔬 Introduction: Understanding Type IV Hypersensitivity
Type IV hypersensitivity is a delayed-type hypersensitivity (DTH), unlike immediate hypersensitivity reactions (Types I-III). 🕒
It is T-cell mediated rather than antibody-driven. This means it involves CD4+ T helper cells (Th1, Th17) and CD8+ cytotoxic T cells rather than IgE, IgG, or IgM. 🦠
The response takes 24-72 hours after exposure to an antigen, which is why it is called delayed. ⏳
Examples include contact dermatitis, tuberculosis (TB) skin reactions, granulomatous inflammation, and transplant rejection. 🏥
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🧬 Pathophysiology: How It Works?
1. Sensitization Phase (First Exposure) 🏗️
The antigen (e.g., nickel, TB antigen, or poison ivy urushiol) is processed by antigen-presenting cells (APCs) like macrophages and dendritic cells.
These APCs present the antigen on MHC-II molecules to naïve CD4+ T cells, activating them. ⚡
CD4+ T cells differentiate into Th1 (mainly) and Th17 cells, producing cytokines like IFN-γ and TNF-α.
2. Effector Phase (Second Exposure) 🎯
Upon re-exposure, memory Th1 cells release cytokines (IFN-γ, TNF-α, IL-2), activating macrophages. 🔥
Macrophages become hyperactivated, releasing enzymes, reactive oxygen species (ROS), and inflammatory mediators, leading to tissue destruction. 💣
In some cases, CD8+ T cells also get activated and kill infected or abnormal cells directly. 🗡️
---
📌 Types of Type IV Hypersensitivity Reactions
There are four major subtypes based on mechanisms and clinical presentations:
1️⃣ Contact Hypersensitivity (Eczema & Contact Dermatitis) 🤲🔴
Triggers: Poison ivy, nickel, latex, fragrances, hair dye. 🌿💍🧤
Mechanism: Small molecules (haptens) bind to skin proteins → APCs present them → Th1 cells activate macrophages → local inflammation and rash.
Example: Poison ivy reaction (blisters, redness, itching).
2️⃣ Tuberculin-Type Hypersensitivity (Mantoux Test) 💉🦠
Triggers: Mycobacterium tuberculosis, Histoplasma, Brucella.
Mechanism: Injected PPD (Purified Protein Derivative) activates memory Th1 cells → Macrophages release cytokines → Local induration and erythema within 48-72 hours.
Example: Mantoux (PPD) Test for tuberculosis.
3️⃣ Granulomatous Hypersensitivity (Chronic Inflammation) 🦠⏳
Triggers: TB, Leprosy, Sarcoidosis, Crohn’s disease, Schistosomiasis.
Mechanism: Persistent antigenic stimulation → Th1 cells release IFN-γ → Macrophages transform into epithelioid cells and multinucleated giant cells → Granuloma formation (walling off infection).
Example: TB granuloma with caseous necrosis.
4️⃣ T-cell Mediated Cytotoxicity (Graft Rejection & Autoimmunity) 🏥⚔️
Triggers: Organ transplants, viral infections, Type 1 Diabetes, Hashimoto’s thyroiditis.
Mechanism: CD8+ T cells recognize infected or foreign cells and kill them via perforins and granzymes.
Yasser’s Electrocardiographic Palpitations Wave with Bilobed Apical Floating ...YasserMohammedHassan1
Bilobed Apex heart with Floating Heart syndrome is an innovative cardiovascular and radiological discovery. The Bilobed Apex heart with Floating Heart syndrome with "Yasser’s Electrocardiographic Palpitations Waves" and off-phenomenon post-amiodarone IVB injection are remarkable innovative constellations. "Yasser’s Electrocardiographic Palpitations Waves" was shortly described as a superficial upright wave associated with unusual palpitations. Bilobed Apex heart with Floating Heart has no known cause. It is mostly congenital. The senses of sudden heart stoppage, generalized fatigue, vertigo, acute confusion, generalized body relaxation, a sense of separation from the environment, and a sense of no abnormality within minutes of amiodarone IVB injection are an off phenomenon.
Co-Chairs and Presenters, Professor Carel le Roux, MBChB, FRCP, FRCPath, PhD, and Donna H. Ryan, MD, FTOS, discuss obesity in this CME activity titled “Adopting Modern Management Strategies for Obesity: Treating the Patient, Not the Disease.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/40HfQWa. CME credit will be available until March 27, 2026.