Regularly drinking green tea could protect the brain against forms of dementia including Alzheimer's, a study published today shows.
It could also play a vital role in protecting the body against cancer, the study in the journal Phytomedicine suggests.
Led by Ed Okello, the Newcastle University team wanted to know if the protective properties known to be present in the freshly brewed form are still active once the tea has been digested.
Dr Okello, from the university's School of Agriculture, Food and Rural Development, said: "What was really exciting about this study was that we found when green tea is digested by enzymes in the gut, the resulting chemicals are actually more effective against key triggers of Alzheimer's development than the undigested form of the tea.
"In addition to this, we also found the digested compounds had anti-cancer properties, significantly slowing down the growth of the tumour cells which we were using in our experiments."
Digestion is a vital process which provides our bodies with the nutrients we need to survive. But nutrients are not necessarily absorbed into the body once food is digested. "It's one of the reasons why we have to be so careful when we make claims about the health benefits of various foods and supplements," Okello said.
"There are certain chemicals we know to be beneficial and we can identify foods which are rich in them but what happens during the digestion process is crucial to whether these foods are actually doing us any good."
As part of the research, the Newcastle team worked in collaboration with Dr Gordon McDougall of the Plant Products and Food Quality Group at the Scottish Crop Research Institute in Dundee, who developed technology which simulates the human digestive system.
Two compounds are known to play a significant role in the development of Alzheimer's disease: hydrogen peroxide and a protein known as beta-amyloid. Previous studies have shown that compounds known as polyphenols, present in black and green tea, possess neuroprotective properties, binding with the toxic compounds and protecting the brain cells.
When ingested, the polyphenols are broken down to produce a mix of compounds and it was these the Newcastle team tested in their latest research.
Carrying out the experiments in the lab using a tumour cell model, they exposed the cells to varying concentrations of the different toxins and the digested green tea compounds.
Okello explained: "The digested chemicals protected the cells, preventing the toxins from destroying the cells. We also saw them affecting the cancer cells, significantly slowing down their growth.
"Green tea has been used in traditional Chinese medicine for centuries and what we have here provides the scientific evidence why it may be effective against some of the key diseases we face today."
The next step is to discover whether the beneficial compounds are produced during digestion after healthy human volunteers consume tea polyphenols.
Okello said: "There are obviously many factors which together have an influence on diseases such as cancer and dementia – a good diet, plenty of exercise and a healthy lifestyle are all important. But I think it's fair to say that at least one cup of green tea every day may be good for you and I would certainly recommend it."
