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A huge study paints the most detailed picture yet of the toll pregnancy and childbirth take on the body. Plus, scientists have discovered a new antibiotic in a lab technician’s garden and artificial intelligence tools are making their way into the process of peer review — to some researchers’ dismay.
As the early Earth solidified, gravitational segregation of dense, iron-rich melts drove mantle evolution, injecting geochemical signatures of shallow silicate fractionation into the deep mantle and inevitably forming a basal magma ocean.
The tumour-suppressor protein BRCA2 is discovered to have a previously undescribed role in maintaining genomic integrity and the sensitivity of PARP1 inhibitors.
Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive oxygen species signals.
Exome sequencing of 851 trios from more than 2,500 individuals finds 187 genes with de novo mutations that contribute to meningomyelocele (spina bifida) and highlights critical pathways required for neural tube closure.